HIV Prevention Medication (PrEP and PEP)

PrEP (Pre-Exposure Prophylaxis) is a prescription medication taken to reduce the risk of HIV infection. When used as prescribed, PrEP can lower the chance of HIV transmission through sexual activity by 99%.

PrEP is recommended for individuals who are HIV-negative and at higher risk of acquiring HIV. This includes people who:

• Have sexual partners with unknown or positive HIV status
• Share needles or syringes
• Have recently been diagnosed with an STD or engage in behaviors with higher HIV transmission risk

There are three FDA-approved PrEP options:

• Truvada (F/TDF): A daily oral medication
• Descovy (F/TAF): Another daily oral medication
• Apretude: A long-acting injectable given every 8 weeks

Work with your healthcare provider to choose the best option. Factors include:

• Your risk of HIV exposure
• Your ability to adhere to a daily medication routine
• Your preference for injections versus oral pills

You must confirm your HIV-negative status through testing before starting PrEP. Routine HIV testing is required every 3 months for oral PrEP or every 8 weeks for injectable PrEP.

PrEP medications are generally well-tolerated. Some users may experience mild side effects like nausea or headaches. Speak with your provider about any concerns.

There are three usage options:

• Daily PrEP: For consistent protection against unpredictable exposures
• On-Demand PrEP: For men who have sex with men, involving pills taken before and after specific exposures
• Long-Acting Injectable PrEP: Administered by a healthcare provider every 8 weeks

PrEP is prescribed by healthcare providers. HIV/STD Testing & Service Locations

Facilities offering PrEP in Alaska include:

• Planned Parenthood (Anchorage & Fairbanks)
• Anchorage Neighborhood Health Center
• Alaska Native Medical Center (statewide for tribal health beneficiaries)
• Infectious Disease Management Group (telehealth options available)

To find a PrEP provider near you, visit locator.hiv.gov. 

Most health insurance plans, including Medicaid and Medicare, cover the cost of PrEP without co-pays. This includes medication, medical appointments, and lab tests associated with PrEP. Some health insurance plans may require prior approval. For people without access to health insurance with prescription drug coverage, financial assistance may be available.

PEP (Post-Exposure Prophylaxis) is a medication taken to prevent HIV infection after a potential exposure. It must be started within 72 hours of exposure and taken daily for 28 days.

PEP is for emergency use only and is recommended if you think you may have been exposed to HIV through:

• Condom failure during sex
• Sharing needles or syringes
• Sexual assault or other high-risk situations
• sex without a condom, barrier, or PrEP

If taken correctly within 72 hours of exposure, PEP is highly effective in preventing HIV infection. Starting sooner increases its effectiveness.

The CDC recommends a 28-day regimen of three antiretroviral drugs, such as:

• Tenofovir disoproxil fumarate (TDF) + emtricitabine (FTC) once daily, combined with raltegravir (RAL) or dolutegravir (DTG)

Most people experience mild side effects, such as fatigue or gastrointestinal discomfort. Discuss concerns with your provider.

Contact your healthcare provider, an urgent care facility, or an emergency room as soon as possible after exposure. If you're unable to afford PEP, assistance programs may provide medications at reduced or no cost.

Private insurance, Medicaid, Medicare, and worker's compensation usually cover PEP. If insurance doesn't cover it, you can apply for free medications through the manufacturer's assistance programs, with urgent requests often processed more quickly to avoid delays.

Applications can be completed online, by phone, or by fax using Gilead.